Orphan Diseases
Amebae-associated infection (Acanthamoeba spp., Entamoeba histolytica, and Naegleria fowleri)
Chancroid (Haemophilus ducreyi)
Coccidiodomycosis (Coccidioides immitis/posodasiI)
Encephalitis (caused by viral agents)
Hansen’s Disease (Leprosy [Mycobacterium leprae])
Histoplasmosis (Histoplasma capsulatum)
Kawasaki disease (mucocutaneous lymph node syndrome)
Legionellosis (Legionella species)
Meningitis, including viral, bacterial, and fungal (non-vaccine preventable)
Necrotizing fasciitis
Rheumatic fever, acute (cases meeting the Jones criteria only)
Toxic shock syndrome
Transmissible spongiform encephalopathies (Gerstmann–Sträussler–Scheinker syndrome, fatal familial insomnia, kuru, variably protease-sensitive prionopathy, Creutzfeldt–Jakob disease, new variant Creutzfeldt–Jakob disease)